ติดตาม
Johnathan Guest
Johnathan Guest
Postdoc, AstraZeneca
ยืนยันอีเมลแล้วที่ astrazeneca.com
ชื่อ
อ้างโดย
อ้างโดย
ปี
Blind prediction of homo‐and hetero‐protein complexes: The CASP13‐CAPRI experiment
MF Lensink, G Brysbaert, N Nadzirin, S Velankar, RAG Chaleil, T Gerguri, ...
Proteins: Structure, Function, and Bioinformatics 87 (12), 1200-1221, 2019
1172019
Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
MF Lensink, G Brysbaert, T Mauri, N Nadzirin, S Velankar, RAG Chaleil, ...
Proteins: Structure, Function, and Bioinformatics 89 (12), 1800-1823, 2021
812021
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants
JD Guest, T Vreven, J Zhou, I Moal, JR Jeliazkov, JJ Gray, Z Weng, ...
Structure 29 (6), 606-621. e5, 2021
762021
Zika virus NS5 protein antagonizes type I interferon production via blocking TBK1 activation
S Lin, S Yang, J He, JD Guest, Z Ma, L Yang, BG Pierce, Q Tang, ...
Virology 527, 180-187, 2019
712019
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
R Gopal, K Jackson, N Tzarum, L Kong, A Ettenger, J Guest, JM Pfaff, ...
PLoS pathogens 13 (12), e1006735, 2017
702017
CoV3D: a database of high resolution coronavirus protein structures
R Gowthaman, JD Guest, R Yin, J Adolf-Bryfogle, WR Schief, BG Pierce
Nucleic acids research 49 (D1), D282-D287, 2021
672021
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design
ZY Keck, BG Pierce, P Lau, J Lu, Y Wang, A Underwood, RA Bull, ...
PLoS pathogens 15 (5), e1007772, 2019
582019
Antigenicity and immunogenicity of differentially glycosylated hepatitis C virus E2 envelope proteins expressed in mammalian and insect cells
RA Urbanowicz, R Wang, JE Schiel, Z Keck, MC Kerzic, P Lau, ...
Journal of virology 93 (7), 10.1128/jvi. 01403-18, 2019
562019
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors
D Wu, A Kolesnikov, R Yin, JD Guest, R Gowthaman, A Shmelev, ...
Nature Communications 13 (1), 19, 2022
272022
An antigenically diverse, representative panel of envelope glycoproteins for hepatitis C virus vaccine development
JH Salas, RA Urbanowicz, JD Guest, N Frumento, A Figueroa, KE Clark, ...
Gastroenterology 162 (2), 562-574, 2022
232022
Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization
BG Pierce, ZY Keck, R Wang, P Lau, K Garagusi, K Elkholy, EA Toth, ...
Journal of virology 94 (22), 10.1128/jvi. 00704-20, 2020
232020
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer
JD Guest, R Wang, KH Elkholy, A Chagas, KL Chao, TE Cleveland IV, ...
Proceedings of the National Academy of Sciences 118 (3), e2015149118, 2021
222021
Computational modeling of hepatitis C virus envelope glycoprotein structure and recognition
JD Guest, BG Pierce
Frontiers in Immunology 9, 367934, 2018
182018
Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials
B Ahani, KM Tuffy, AA Aksyuk, D Wilkins, ME Abram, R Dagan, ...
Nature Communications 14 (1), 4347, 2023
172023
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants
R Yin, JD Guest, G Taherzadeh, R Gowthaman, I Mittra, J Quackenbush, ...
PLoS Computational Biology 17 (9), e1009380, 2021
17*2021
Impact of AlphaFold on structure prediction of protein complexes: the CASP15‐CAPRI experiment
MF Lensink, G Brysbaert, N Raouraoua, PA Bates, M Giulini, RV Honorato, ...
Proteins: Structure, Function, and Bioinformatics 91 (12), 1658-1683, 2023
162023
Structure-based and rational design of a hepatitis C virus vaccine
JD Guest, BG Pierce
Viruses 13 (5), 837, 2021
92021
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate
R Wang, S Suzuki, JD Guest, B Heller, M Almeda, AK Andrianov, A Marin, ...
Proceedings of the National Academy of Sciences 119 (11), e2112008119, 2022
82022
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
MC Metcalf, BM Janus, R Yin, R Wang, JD Guest, E Pozharski, M Law, ...
Nature Communications 14 (1), 3980, 2023
52023
Molecular characterization of AZD7442 (tixagevimab-cilgavimab) neutralization of SARS-CoV-2 Omicron subvariants
TL Roe, T Brady, N Schuko, A Nguyen, J Beloor, JD Guest, AA Aksyuk, ...
Microbiology Spectrum 11 (2), e00333-23, 2023
52023
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บทความ 1–20