Bacterial cGAS-like enzymes synthesize diverse nucleotide signals AT Whiteley, JB Eaglesham, CC de Oliveira Mann, BR Morehouse, ... Nature 567 (7747), 194-199, 2019 | 302 | 2019 |
Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ... Cell 174 (2), 300-311. e11, 2018 | 279 | 2018 |
STING cyclic dinucleotide sensing originated in bacteria BR Morehouse, AA Govande, A Millman, AFA Keszei, B Lowey, G Ofir, ... Nature 586 (7829), 429-433, 2020 | 269 | 2020 |
CBASS immunity uses CARF-related effectors to sense 3′–5′-and 2′–5′-linked cyclic oligonucleotide signals and protect bacteria from phage infection B Lowey, AT Whiteley, AFA Keszei, BR Morehouse, IT Mathews, ... Cell 182 (1), 38-49. e17, 2020 | 151 | 2020 |
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages N Tal, BR Morehouse, A Millman, A Stokar-Avihail, C Avraham, ... Cell 184 (23), 5728-5739. e16, 2021 | 146 | 2021 |
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila KM Slavik, BR Morehouse, AE Ragucci, W Zhou, X Ai, Y Chen, L Li, Z Wei, ... Nature 597 (7874), 109-113, 2021 | 114 | 2021 |
Viruses inhibit TIR gcADPR signaling to overcome bacterial defense A Leavitt, E Yirmiya, G Amitai, A Lu, J Garb, BR Morehouse, SJ Hobbs, ... Nature 611, 326–331, 2022 | 84 | 2022 |
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity SJ Hobbs, T Wein, A Lu, BR Morehouse, J Schnabel, A Leavitt, E Yirmiya, ... Nature 605 (7910), 522-526, 2022 | 72 | 2022 |
Functional and Structural Characterization of a (+)-Limonene Synthase from Citrus sinensis BR Morehouse, RP Kumar, JO Matos, SN Olsen, S Entova, DD Oprian Biochemistry 56 (12), 1706-1715, 2017 | 57 | 2017 |
Cryo-EM structure of an active bacterial TIR–STING filament complex BR Morehouse, MCJ Yip, AFA Keszei, NK McNamara-Bordewick, S Shao, ... Nature 608 (7924), 803-807, 2022 | 47 | 2022 |
Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate … RP Kumar, BR Morehouse, JO Matos, K Malik, H Lin, IJ Krauss, ... Biochemistry 56 (12), 1716-1725, 2017 | 39 | 2017 |
cGLRs are a diverse family of pattern recognition receptors in innate immunity Y Li, KM Slavik, HC Toyoda, BR Morehouse, CC de Oliveira Mann, A Elek, ... Cell 186 (15), 3261-3276. e20, 2023 | 26 | 2023 |
Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC RP Kumar, BR Morehouse, J Fofana, MM Trieu, DH Zhou, MO Lorenz, ... Journal of Biological Chemistry 292 (52), 21578-21589, 2017 | 18 | 2017 |
Direct evidence of an enzyme-generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog BR Morehouse, RP Kumar, JO Matos, Q Yu, A Bannister, K Malik, ... ACS chemical biology 14 (9), 2035-2043, 2019 | 14 | 2019 |
cGLRs are a diverse family of pattern recognition receptors in animal innate immunity Y Li, KM Slavik, BR Morehouse, CC de Oliveira Mann, K Mears, J Liu, ... bioRxiv, 2023 | 3 | 2023 |
Phage defense origin of animal immunity BR Morehouse Current Opinion in Microbiology 73, 102295, 2023 | 2 | 2023 |
Pharmacological potential of cyclic nucleotide signaling in immunity EMQ Ednacot, A Nabhani, DM Dinh, BR Morehouse Pharmacology & Therapeutics, 108653, 2024 | | 2024 |
An OLD protein teaches us new tricks: prokaryotic antiviral defense EMQ Ednacot, BR Morehouse nature communications 15 (1), 2527, 2024 | | 2024 |
Say YES to single-gene lysis! A Nabhani, BR Morehouse Cell Host & Microbe 31 (9), 1420-1422, 2023 | | 2023 |
Cyclic CMP and cyclic UMP in bacterial immunity BR Morehouse, N Tal, NK McNamara-Bordewick, AFA Keszei, S Shao, ... JOURNAL OF TRANSLATIONAL MEDICINE 21 (SUPPL 1), 2023 | | 2023 |