| FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases R Furumai, A Matsuyama, N Kobashi, KH Lee, M Nishiyama, H Nakajima, ... Cancer research 62 (17), 4916-4921, 2002 | 1028 | 2002 |
| Histone deacetylase as a new target for cancer chemotherapy M Yoshida, R Furumai, M Nishiyama, Y Komatsu, N Nishino, S Horinouchi Cancer chemotherapy and pharmacology 48, S20-S26, 2001 | 326 | 2001 |
| X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction M Kukimoto, M Nishiyama, MEP Murphy, S Turley, ET Adman, ... Biochemistry 33 (17), 5246-5252, 1994 | 192 | 1994 |
| Determinants of protein thermostability observed in the 1.9-. ANG. crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus CA Kelly, M Nishiyama, Y Ohnishi, T Beppu, JJ Birktoft Biochemistry 32 (15), 3913-3922, 1993 | 177 | 1993 |
| Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2) S Horinouchi, M Kito, M Nishiyama, K Furuya, SK Hong, K Miyake, ... Gene 95 (1), 49-56, 1990 | 176 | 1990 |
| Amidase coupled with low‐molecular‐mass nitrile hydratase from Rhodococcus rhodochrous J1: Sequencing and expression of the gene and purification and … M Kobayashi, H KOMEDA, T NAGASAWA, M NISHIYAMA, ... European Journal of Biochemistry 217 (1), 327-336, 1993 | 172 | 1993 |
| Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23 M Nishiyama, S Horinouchi, M Kobayashi, T Nagasawa, H Yamada, ... Journal of bacteriology 173 (8), 2465-2472, 1991 | 168 | 1991 |
| Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways G Schendzielorz, M Dippong, A Grunberger, D Kohlheyer, A Yoshida, ... ACS synthetic biology 3 (1), 21-29, 2014 | 164 | 2014 |
| Cloning, nucleotide sequence and expression in Escherichia coli of two cobalt-containing nitrile hydratase genes from Rhodococcus rhodochrous J1 M Kobayashi, M Nishiyama, T Nagasawa, S Horinouchi, T Beppu, ... Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1129 (1 …, 1991 | 153 | 1991 |
| Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase MJ Boulanger, M Kukimoto, M Nishiyama, S Horinouchi, MEP Murphy Journal of Biological Chemistry 275 (31), 23957-23964, 2000 | 146 | 2000 |
| A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis H Nishida, M Nishiyama, N Kobashi, T Kosuge, T Hoshino, H Yamane Genome Research 9 (12), 1175-1183, 1999 | 143 | 1999 |
| Primary structure of nitrile hydratase deduced from the nucleotide sequence of a Rhodococcus species and its expression in Escherichia coli O Ikehata, M Nishiyama, S Horinouchi, T Beppu European journal of biochemistry 181 (3), 563-570, 1989 | 143 | 1989 |
| Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities T Kumano, SB Richard, JP Noel, M Nishiyama, T Kuzuyama Bioorganic & medicinal chemistry 16 (17), 8117-8126, 2008 | 141 | 2008 |
| Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon Source S Kosono, M Tamura, S Suzuki, Y Kawamura, A Yoshida, M Nishiyama, ... PloS one 10 (6), e0131169, 2015 | 139 | 2015 |
| Molecular cloning and characterization of a cDNA encoding ent‐cassa‐12,15‐diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from … EM Cho, A Okada, H Kenmoku, K Otomo, T Toyomasu, W Mitsuhashi, ... The Plant Journal 37 (1), 1-8, 2004 | 128 | 2004 |
| Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases SY Kim, P Zhao, M Igarashi, R Sawa, T Tomita, M Nishiyama, ... Chemistry & biology 16 (7), 736-743, 2009 | 118 | 2009 |
| Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+ 2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides T Hashimoto, J Hashimoto, K Teruya, T Hirano, K Shin-ya, H Ikeda, H Liu, ... Journal of the American Chemical Society 137 (2), 572-575, 2015 | 116 | 2015 |
| Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc MEP Murphy, S Turley, M Kukimoto, M Nishiyama, S Horinouchi, H Sasaki, ... Biochemistry 34 (38), 12107-12117, 1995 | 116 | 1995 |
| Nucleotide sequence of the streptothricin acetyltransferase gene from Streptomyces lavendulae and its expression in heterologous hosts S Horinouchi, K Furuya, M Nishiyama, H Suzuki, T Beppu Journal of bacteriology 169 (5), 1929-1937, 1987 | 116 | 1987 |
| Nucleotide sequence of the malate dehydrogenase gene of Thermus flavus and its mutation directing an increase in enzyme activity. M Nishiyama, N Matsubara, K Yamamoto, S Iijima, T Uozumi, T Beppu Journal of Biological Chemistry 261 (30), 14178-14183, 1986 | 114 | 1986 |
