| Lifetime cancer risks in individuals with germline PTEN mutations MH Tan, JL Mester, J Ngeow, LA Rybicki, MS Orloff, C Eng Clinical Cancer Research 18 (2), 400-407, 2012 | 1000 | 2012 |
| A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands MH Tan, J Mester, C Peterson, Y Yang, JL Chen, LA Rybicki, K Milas, ... The American Journal of Human Genetics 88 (1), 42-56, 2011 | 412 | 2011 |
| Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers B Heald, J Mester, L Rybicki, MS Orloff, CA Burke, C Eng Gastroenterology 139 (6), 1927-1933, 2010 | 311 | 2010 |
| Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes Y Ni, KM Zbuk, T Sadler, A Patocs, G Lobo, E Edelman, P Platzer, ... The American Journal of Human Genetics 83 (2), 261-268, 2008 | 245 | 2008 |
| Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes MS Orloff, X He, C Peterson, F Chen, JL Chen, JL Mester, C Eng The American Journal of Human Genetics 92 (1), 76-80, 2013 | 218 | 2013 |
| Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome MS Orloff, C Eng Oncogene 27 (41), 5387-5397, 2008 | 149 | 2008 |
| Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma M Orloff, C Peterson, X He, S Ganapathi, B Heald, Y Yang, G Bebek, ... JAmA 306 (4), 410-419, 2011 | 146 | 2011 |
| Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling X He, Y Wang, J Zhu, M Orloff, C Eng Cancer letters 301 (2), 168-176, 2011 | 141 | 2011 |
| Subtypes of familial breast tumours revealed by expression and copy number profiling N Waddell, J Arnold, S Cocciardi, L Da Silva, A Marsh, J Riley, ... Breast cancer research and treatment 123, 661-677, 2010 | 132 | 2010 |
| Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53 Y Ni, X He, J Chen, J Moline, J Mester, MS Orloff, MD Ringel, C Eng Human molecular genetics 21 (2), 300-310, 2012 | 122 | 2012 |
| Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and-independent mechanisms in prostate cancer cell lines Y Wang, T Romigh, X He, MS Orloff, RH Silverman, WD Heston, C Eng Human molecular genetics 19 (22), 4319-4329, 2010 | 121 | 2010 |
| Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers Y Wang, T Romigh, X He, MH Tan, MS Orloff, RH Silverman, WD Heston, ... Oncogene 30 (42), 4327-4338, 2011 | 108 | 2011 |
| Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma DE Hansel, E Platt, M Orloff, J Harwalker, S Sethu, JL Hicks, A De Marzo, ... The American journal of pathology 176 (6), 3062-3072, 2010 | 100 | 2010 |
| PARP1 is up-regulated in non-small cell lung cancer tissues in the presence of the cyanobacterial toxin microcystin PL Apopa, L Alley, RB Penney, K Arnaoutakis, MA Steliga, S Jeffus, ... Frontiers in microbiology 9, 1757, 2018 | 90 | 2018 |
| Frequency of Germline PTEN Mutations in Differentiated Thyroid Cancer R Nagy, S Ganapathi, I Comeras, C Peterson, M Orloff, K Porter, C Eng, ... Thyroid 21 (5), 505-510, 2011 | 86 | 2011 |
| Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps J Ngeow, B Heald, LA Rybicki, MS Orloff, JL Chen, X Liu, L Yerian, J Willis, ... Gastroenterology 144 (7), 1402-1409. e5, 2013 | 81 | 2013 |
| Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer MH Tan, S De, G Bebek, MS Orloff, R Wesolowski, E Downs-Kelly, ... Breast cancer research and treatment 131, 849-858, 2012 | 73 | 2012 |
| Variants in the Wilms’ tumor gene are associated with focal segmental glomerulosclerosis in the African American population MS Orloff, SK Iyengar, CA Winkler, KAB Goddard, RA Dart, TS Ahuja, ... Physiological genomics 21 (2), 212-221, 2005 | 72 | 2005 |
| Genomic alterations in tumor stroma C Eng, G Leone, MS Orloff, MC Ostrowski Cancer research 69 (17), 6759-6764, 2009 | 63 | 2009 |
| Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes S Ashida, MS Orloff, G Bebek, L Zhang, P Zheng, DM Peehl, C Eng Clinical Cancer Research 18 (6), 1578-1587, 2012 | 48 | 2012 |
