Tom Huxford
Tom Huxford
Professor of Chemistry & Biochemistry, San Diego State University
Verified email at - Homepage
Cited by
Cited by
The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation
T Huxford, DB Huang, S Malek, G Ghosh
Cell 95 (6), 759-770, 1998
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
SB Hansen, G Sulzenbacher, T Huxford, P Marchot, P Taylor, Y Bourne
The EMBO journal 24 (20), 3635-3646, 2005
IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells
S Malek, Y Chen, T Huxford, G Ghosh
Journal of Biological Chemistry 276 (48), 45225-45235, 2001
IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB
S Malek, T Huxford, G Ghosh
Journal of Biological Chemistry 273 (39), 25427-25435, 1998
X-ray crystal structure of an IκBβ· NF-κB p65 homodimer complex
S Malek, DB Huang, T Huxford, S Ghosh, G Ghosh
Journal of Biological Chemistry 278 (25), 23094-23100, 2003
NF-κB, IκB, and IKK: integral components of immune system signaling
MC Mulero, T Huxford, G Ghosh
Structural Immunology, 207-226, 2019
A structural guide to proteins of the NF-κB signaling module
T Huxford, G Ghosh
Cold Spring Harbor perspectives in biology 1 (3), a000075, 2009
Mechanism of IκBα binding to NF-κB dimers
CB Phelps, LL Sengchanthalangsy, T Huxford, G Ghosh
Journal of Biological Chemistry 275 (38), 29840-29846, 2000
Biophysical characterization of the free IκBα ankyrin repeat domain in solution
CH Croy, S Bergqvist, T Huxford, G Ghosh, EA Komives
Protein Science 13 (7), 1767-1777, 2004
A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation
S Polley, DB Huang, AV Hauenstein, AJ Fusco, X Zhong, D Vu, ...
PLoS biology 11 (6), e1001581, 2013
The role of DNA in the mechanism of NFκB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits
DB Huang, T Huxford, YQ Chen, G Ghosh
Structure 5 (11), 1427-1436, 1997
Structure and mechanism in NF-κB/IκB signaling
T Huxford, S Malek, G Ghosh
Cold Spring Harbor symposia on quantitative biology 64, 533-540, 1999
The nuclear IκB protein IκBζ specifically binds NF-κB p50 homodimers and forms a ternary complex on κB DNA
DV Trinh, N Zhu, G Farhang, BJ Kim, T Huxford
Journal of molecular biology 379 (1), 122-135, 2008
Genome reading by the NF-κB transcription factors
MC Mulero, VYF Wang, T Huxford, G Ghosh
Nucleic acids research 47 (19), 9967-9989, 2019
Thermodynamics reveal that helix four in the NLS of NF-κB p65 anchors IκBα, forming a very stable complex
S Bergqvist, CH Croy, M Kjaergaard, T Huxford, G Ghosh, EA Komives
Journal of molecular biology 360 (2), 421-434, 2006
The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen
JM Wojciak, N Zhu, KT Schuerenberg, K Moreno, WS Shestowsky, ...
Proceedings of the National Academy of Sciences 106 (42), 17717-17722, 2009
Molecular mimicry of the NF-κB DNA target site by a selected RNA aptamer
G Ghosh, DB Huang, T Huxford
Current opinion in structural biology 14 (1), 21-27, 2004
X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster
CF Lee, AV Hauenstein, JK Fleming, WC Gasper, V Engelke, B Sankaran, ...
Structure 19 (3), 397-408, 2011
Understanding the logic of IκB: NF-κB regulation in structural terms
T Huxford, A Hoffmann, G Ghosh
NF-kB in Health and Disease, 1-24, 2011
Solvent exposed non-contacting amino acids play a critical role in NF-κB/IκBα complex formation
T Huxford, D Mishler, CB Phelps, DB Huang, LL Sengchanthalangsy, ...
Journal of molecular biology 324 (4), 587-597, 2002
The system can't perform the operation now. Try again later.
Articles 1–20