After nerve injury, lineage tracing shows that myelin and Remak Schwann cells elongate extensively and branch to form repair Schwann cells, which shorten radically on remyelination JA Gomez-Sanchez, KS Pilch, M van der Lans, SV Fazal, C Benito, ... Journal of Neuroscience 37 (37), 9086-9099, 2017 | 239 | 2017 |
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis AM Nicaise, LJ Wagstaff, CM Willis, C Paisie, H Chandok, P Robson, ... Proceedings of the National Academy of Sciences 116 (18), 9030-9039, 2019 | 195 | 2019 |
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun LJ Wagstaff, JA Gomez-Sanchez, SV Fazal, GW Otto, AM Kilpatrick, ... Elife 10, e62232, 2021 | 89 | 2021 |
Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, remyelination, tumorigenesis, and hypomyelination SV Fazal, JA Gomez-Sanchez, LJ Wagstaff, N Musner, G Otto, M Janz, ... Journal of Neuroscience 37 (50), 12297-12313, 2017 | 84 | 2017 |
c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy J Hantke, L Carty, LJ Wagstaff, M Turmaine, DK Wilton, S Quintes, ... Brain 137 (11), 2922-2937, 2014 | 80 | 2014 |
Reprogramming of fibroblasts to oligodendrocyte progenitor-like cells using CRISPR/Cas9-based synthetic transcription factors M Matjusaitis, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, ... Stem cell reports 13 (6), 1053-1067, 2019 | 25 | 2019 |
Age-related loss of axonal regeneration is reflected by the level of local translation S van Erp, AA van Berkel, EM Feenstra, PK Sahoo, LJ Wagstaff, JL Twiss, ... Experimental Neurology 339, 113594, 2021 | 12 | 2021 |
A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode D Marafi, N Kozar, R Duan, S Bradley, K Yokochi, F Al Mutairi, NW Saadi, ... The American Journal of Human Genetics 109 (9), 1713-1723, 2022 | 9 | 2022 |
The relationship between Schwann cell c-Jun and regeneration failures due to ageing and long-term injury LJ Wagstaff, JA Gomez-Sanchez, R Mirsky, KR Jessen 13th European Meeting on Glial Cells in Health and Disease, 2017 | 8 | 2017 |
Manipulation of repair Schwann cells to correct regeneration failures due to chronic denervation and advancing age KR Jessen, LJ Wagstaff, JA Gomez-Sanchez, R Mirsky 13th European Meeting on Glial Cells in Health and Disease, 2017 | 2 | 2017 |
Gene expression in rejuvenated repair Schwann cells in aged mice or in chronic injured nerves. JA Gomez-Sanchez, L Wagstaff, G Otto, R Mirsky, KR Jessen GLIA 67, E652-E653, 2019 | 1 | 2019 |
Enhancing remyelination with CRISPR/Cas9 edited human oligodendrocyte progenitor cells L Wagstaff, M Kaczmarek, A Fidanza, RJM Franklin, AC Williams GLIA 69, E521-E521, 2021 | | 2021 |
The well documented failures of nerve repair seen during aging and chronic denervation involve reduced Schwann cell c-Jun, and are rescued by restoring c-Jun levels. KR Jessen, LJ Wagstaff, JA Gomez-Sanchez, SV Fazal, P Arthur-Farraj, ... GLIA 69, E88-E89, 2021 | | 2021 |
Promoting oligodendroglia differentiation from hEScells using an inducible CRISPRa system T Tsarouchas, L Wagstaff, NL Kazakou, A Williams GLIA 69, E258-E259, 2021 | | 2021 |
Enhancing remyelination with CRISPR/Cas9 edited human oligodendrocyte precursor cells LJ Wagstaff, A Fidanza, RJM Franklin, AC Williams GLIA 67, E666-E666, 2019 | | 2019 |
Emerging Drugs and Targets for Remyelination in Multiple Sclerosis LJ Wagstaff, A Williams Emerging Drugs and Targets for Multiple Sclerosis 70, 199, 2019 | | 2019 |
The role of Schwann cell c-Jun in restoring axon regeneration deficits in the peripheral nervous system LJ Wagstaff UCL (University College London), 2018 | | 2018 |
Failures of nerve regeneration caused by aging or chronic denervation are rescued by 2 LJ Wagstaff, JA Gomez-Sanchez, V Fazal, W Otto METHODS 539, 540, 0 | | |